Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis
Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the ‘Warburg effect’, which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIRT1 is a molecular signature of primed hPSCs and that SI...
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Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5545746
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5545746
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ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/ncb3517
