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Epithelial calcineurin controls microbiota-dependent intestinal tumor development

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Epithelial calcineurin controls microbiota-dependent intestinal tumor development

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5570457

Epithelial calcineurin controls microbiota-dependent intestinal tumor development

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Publication information

Publisher

New York: Nature Publishing Group US

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Subjects and topics

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Scope and Contents

Contents

The intestinal microbiota signals through epithelial cells to activate calcineurin and NFAT, driving proliferation of cancer stem cells and the development of colorectal cancer.
Inflammation-associated pathways are active in intestinal epithelial cells (IECs) and contribute to the pathogenesis of colorectal cancer (CRC). Calcineurin, a phosphata...

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Full title

Epithelial calcineurin controls microbiota-dependent intestinal tumor development

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5570457

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5570457

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ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/nm.4072

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