PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer
PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer
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Author / Creator
Modi, D A , Tagare, R D , Karthikeyan, S , Russo, A , Dean, M , Davis, D A , Lantvit, D D and Burdette, J E
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The fallopian tube epithelium (FTE) is one of the progenitor populations for high-grade serous ovarian cancer (HGSC). Loss of PAX2 is the earliest known molecular aberration in the FTE occurring in serous carcinogenesis followed by a mutation in p53. Pathological studies report consistent loss of PAX2 in benign lesions as well as serous tumors. In...
Alternative Titles
Full title
PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer
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Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5581540
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5581540
Other Identifiers
ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/onc.2016.455
