The role of MAP2 kinases and p38 kinase in acute murine liver injury models
The role of MAP2 kinases and p38 kinase in acute murine liver injury models
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
c-Jun N-terminal kinase (JNK) mediates hepatotoxicity through interaction of its phospho-activated form with a mitochondrial outer membrane protein, Sh3bp5 or Sab, leading to dephosphorylation of intermembrane Src and consequent impaired mitochondrial respiration and enhanced ROS release. ROS production from mitochondria activates MAP3 kinases, suc...
Alternative Titles
Full title
The role of MAP2 kinases and p38 kinase in acute murine liver injury models
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5584575
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5584575
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2017.295
