Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II cells (AEC2s). Here we show that local lung hypoxia, through hypoxia-inducible factor (HIF1α),...
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Full title
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5600325
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5600325
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3580
