Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening,...
Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies
About this item
Full title
Author / Creator
Zhang, Yuxin , Wang, Xing , Li, Xi , Peng, Sha , Wang, Shifeng , Huang, Christopher Z. , Huang, Corine Z. , Zhang, Qiao , Li, Dai , Jiang, Jun , Ouyang, Qin , Zhang, Yanling , Li, Shiyou and Qiao, Yanjiang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Bitter taste receptors (TAS2Rs) have attracted a great deal of interest because of their recently described bronchodilator and anti-inflammatory properties. The aim of this study was to identify natural direct TAS2R14 agonists from
Radix Bupleuri
that can inhibit mast cell degranulation. A ligand-based virtual screening was conducted on a lib...
Alternative Titles
Full title
Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5610306
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5610306
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-11720-0
