Metabolic gatekeeper function of B-lymphoid transcription factors
Metabolic gatekeeper function of B-lymphoid transcription factors
About this item
Full title
Author / Creator
Chan, Lai N. , Chen, Zhengshan , Braas, Daniel , Lee, Jae-Woong , Xiao, Gang , Geng, Huimin , Cosgun, Kadriye Nehir , Hurtz, Christian , Shojaee, Seyedmehdi , Cazzaniga, Valeria , Schjerven, Hilde , Ernst, Thomas , Hochhaus, Andreas , Kornblau, Steven M. , Konopleva, Marina , Pufall, Miles A. , Cazzaniga, Giovanni , Liu, Grace J. , Milne, Thomas A. , Koeffler, H. Phillip , Ross, Theodora S. , Sánchez-García, Isidro , Borkhardt, Arndt , Yamamoto, Keith R. , Dickins, Ross A. , Graeber, Thomas G. and Müschen, Markus
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensitizing acute lymphoblastic leukaemia B cells to glucocorticoid therapy.
Metabolic gatekeeper restricts B-cell malignancies
This report e...
Alternative Titles
Full title
Metabolic gatekeeper function of B-lymphoid transcription factors
Authors, Artists and Contributors
Author / Creator
Chen, Zhengshan
Braas, Daniel
Lee, Jae-Woong
Xiao, Gang
Geng, Huimin
Cosgun, Kadriye Nehir
Hurtz, Christian
Shojaee, Seyedmehdi
Cazzaniga, Valeria
Schjerven, Hilde
Ernst, Thomas
Hochhaus, Andreas
Kornblau, Steven M.
Konopleva, Marina
Pufall, Miles A.
Cazzaniga, Giovanni
Liu, Grace J.
Milne, Thomas A.
Koeffler, H. Phillip
Ross, Theodora S.
Sánchez-García, Isidro
Borkhardt, Arndt
Yamamoto, Keith R.
Dickins, Ross A.
Graeber, Thomas G.
Müschen, Markus
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5621518
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5621518
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature21076