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Metabolic gatekeeper function of B-lymphoid transcription factors

Metabolic gatekeeper function of B-lymphoid transcription factors

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5621518

Metabolic gatekeeper function of B-lymphoid transcription factors

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensitizing acute lymphoblastic leukaemia B cells to glucocorticoid therapy.
Metabolic gatekeeper restricts B-cell malignancies
This report e...

Alternative Titles

Full title

Metabolic gatekeeper function of B-lymphoid transcription factors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5621518

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5621518

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature21076

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