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P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression

P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5632310

P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression

About this item

Full title

P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression

Publisher

US: Oxford University Press

Journal title

The international journal of neuropsychopharmacology, 2017-10, Vol.20 (10), p.813-822

Language

English

Formats

Publication information

Publisher

US: Oxford University Press

More information

Scope and Contents

Contents

BackgroundMajor depressive disorder is characterized by structural and functional abnormalities of cortical and limbic brain areas, including a decrease in spine synapse number in the dentate gyrus of the hippocampus. Recent studies highlighted that both genetic and pharmacological invalidation of the purinergic P2X7 receptor (P2rx7) leads to antid...

Alternative Titles

Full title

P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5632310

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5632310

Other Identifiers

ISSN

1461-1457

E-ISSN

1469-5111

DOI

10.1093/ijnp/pyx046

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