Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell...
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
About this item
Full title
Author / Creator
Mills, Richard J. , Titmarsh, Drew M. , Koenig, Xaver , Parker, Benjamin L. , Ryall, James G. , Quaife-Ryan, Gregory A. , Voges, Holly K. , Hodson, Mark P. , Ferguson, Charles , Drowley, Lauren , Plowright, Alleyn T. , Needham, Elise J. , Wang, Qing-Dong , Gregorevic, Paul , Xin, Mei , Thomas, Walter G. , Parton, Robert G. , Nielsen, Lars K. , Launikonis, Bradley S. , James, David E. , Elliott, David A. , Porrello, Enzo R. and Hudson, James E.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The mammalian heart undergoes maturation during postnatal life to meet the increased functional requirements of an adult. However, the key drivers of this process remain poorly defined. We are currently unable to recapitulate postnatal maturation in human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), limiting their potential as a model s...
Alternative Titles
Full title
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
Authors, Artists and Contributors
Author / Creator
Titmarsh, Drew M.
Koenig, Xaver
Parker, Benjamin L.
Ryall, James G.
Quaife-Ryan, Gregory A.
Voges, Holly K.
Hodson, Mark P.
Ferguson, Charles
Drowley, Lauren
Plowright, Alleyn T.
Needham, Elise J.
Wang, Qing-Dong
Gregorevic, Paul
Xin, Mei
Thomas, Walter G.
Parton, Robert G.
Nielsen, Lars K.
Launikonis, Bradley S.
James, David E.
Elliott, David A.
Porrello, Enzo R.
Hudson, James E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5635889
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5635889
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1707316114
