Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and significance are unclear. In the present study, USP5 was found to interact with c-Maf and prevented it from degradation by decreasing its polyubiquitination level. Specifically, the 308th and 347th lysine residues in c-Maf were crit...
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Full title
Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5636991
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5636991
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2017.450
