Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
A decrease in ataxin-2 levels leads to a reduction in the aggregation of TDP-43, markedly increased lifespan and improved motor function in a transgenic mouse model of TDP-43 proteinopathy.
Neurodegeneration therapy
Ataxin-2 polyglutamine expansions increase the risk for amyotrophic lateral sclerosis (ALS) and cause spinocerebellar ataxia typ...
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Full title
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5642042
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5642042
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22038
