A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, i...
A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin)
via
scaffold hopping and bioisosteric modification of known inhibitors of α-glucosidase. The design w...
Alternative Titles
Full title
A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5643545
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5643545
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-13798-y
