Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice
Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Identification of the causal effects of specific proteins on recurrent and partially reversible hearing loss has been difficult because of the lack of an animal model that provides reversible gene knockdown. We have developed the transgenic mouse line
Actin
-tTS::
Nkcc1
tetO/tetO
for manipulatable expression of the cochlear K
+
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Full title
Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5648887
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5648887
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-13997-7
