Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal t...
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
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Full title
Author / Creator
Sansone, Pasquale , Savini, Claudia , Kurelac, Ivana , Chang, Qing , Amato, Laura Benedetta , Strillacci, Antonio , Stepanova, Anna , Iommarini, Luisa , Mastroleo, Chiara , Daly, Laura , Galkin, Alexander , Thakur, Basant Kumar , Soplop, Nadine , Uryu, Kunihiro , Hoshino, Ayuko , Norton, Larry , Bonafé, Massimiliano , Cricca, Monica , Gasparre, Giuseppe , Lyden, David and Bromberg, Jacqueline
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit from dormancy have never been investigated. Here we identified the full mitochondrial genome in circulating extracellular vesicles (EVs) from patients with hormonal therapy-resistant (HTR) metastatic breast cancer. We generated xenograft models of HTR metas...
Alternative Titles
Full title
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
Authors, Artists and Contributors
Author / Creator
Savini, Claudia
Kurelac, Ivana
Chang, Qing
Amato, Laura Benedetta
Strillacci, Antonio
Stepanova, Anna
Iommarini, Luisa
Mastroleo, Chiara
Daly, Laura
Galkin, Alexander
Thakur, Basant Kumar
Soplop, Nadine
Uryu, Kunihiro
Hoshino, Ayuko
Norton, Larry
Bonafé, Massimiliano
Cricca, Monica
Gasparre, Giuseppe
Lyden, David
Bromberg, Jacqueline
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5664494
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5664494
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1704862114
