Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of dif...
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support purine and thymidine synthesis, and thus cell growth. Mammals have both cytosolic SHMT1 and mitochondrial SHMT2, with the mitochondrial isozyme strongly up-regulated in cancer. Here we show gene...
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Full title
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5664509
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5664509
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1706617114
