Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis
Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis
About this item
Full title
Author / Creator
Yuan, Huairui , Li, Ni , Fu, Da , Ren, Jiale , Hui, Jingyi , Peng, Junjie , Liu, Yongfeng , Qiu, Tong , Jiang, Min , Pan, Qiang , Han, Ying , Wang, Xiaoming , Li, Qintong and Qin, Jun
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely undefined. Here, we found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse models of colorectal cancer (CRC). SETD2 was not r...
Alternative Titles
Full title
Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5669571
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5669571
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI94292
