The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment
The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment
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Author / Creator
Gane, Edward J. , Metivier, Sophie , Nahass, Ronald , Ryan, Michael , Stedman, Catherine A. , Svarovskaia, Evguenia S. , Mo, Hongmei , Doehle, Brian , Dvory‐Sobol, Hadas , Hedskog, Charlotte , Lin, Ming , Brainard, Diana M. , Yang, Jenny C. , McHutchison, John G. , Sulkowski, Mark , Younes, Ziad and Lawitz, Eric
Publisher
United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Journal title
Language
English
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Publication information
Publisher
United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Subjects
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Scope and Contents
Contents
S282T in NS5B is the primary amino acid substitution associated with resistance to sofosbuvir (SOF) but has rarely been detected in patients treated with a SOF‐based regimen. Here, the emergence and fitness of the S282T substitution in virologic failure patients administered SOF‐based regimens across the SOF and ledipasvir (LDV)/SOF phase 2 and 3 p...
Alternative Titles
Full title
The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5678900
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5678900
Other Identifiers
ISSN
2471-254X
E-ISSN
2471-254X
DOI
10.1002/hep4.1060
