Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential
Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Development of an efficacious, non-addicting analgesic has been challenging. Discovery of novel mechanisms underlying addiction may present a solution. Here we target the neurokinin system, which is involved in both pain and addiction. Morphine exerts its rewarding actions, at least in part, by inhibiting GABAergic input onto substance P (SP) neuro...
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Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5680162
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5680162
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ISSN
1359-4184,1476-5578
E-ISSN
1476-5578
DOI
10.1038/mp.2017.102
