Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of th...
Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The multifunctional, transmembrane glycoprotein human CD38 catalyses the synthesis of three key Ca
2+
-mobilising messengers, including cyclic adenosine 5′-diphosphate ribose (cADPR), and CD38 knockout studies have revealed the relevance of the related signalling pathways to disease. To generate inhibitors of CD38 by total synthesis, analogue...
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Full title
Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5700923
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5700923
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-16388-0
