Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology
Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Tango1 enables ER-to-Golgi trafficking of large proteins. We show here that loss of Tango1, in addition to disrupting protein secretion and ER/Golgi morphology, causes ER stress and defects in cell shape. We find that the previously observed dependence of smaller cargos on Tango1 is a secondary effect. If large cargos like Dumpy, which we identify...
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Full title
Dual function for Tango1 in secretion of bulky cargo and in ER-Golgi morphology
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5715762
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5715762
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1711408114
