Computational insights for the hydride transfer and distinctive roles of key residues in cholesterol...
Computational insights for the hydride transfer and distinctive roles of key residues in cholesterol oxidase
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Cholesterol oxidase (ChOx), a member of the glucose-methanol-choline (GMC) family, catalyzes the oxidation of the substrate
via
a hydride transfer mechanism and concomitant reduction of the FAD cofactor. Unlike other GMC enzymes, the conserved His447 is not the catalytic base that deprotonates the substrate in ChOx. Our QM/MM MD simulations i...
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Full title
Computational insights for the hydride transfer and distinctive roles of key residues in cholesterol oxidase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5722936
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5722936
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-17503-x
