Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The spontaneous deamination of cytosine is a major source of transitions from C•G to T•A base pairs, which account for half of known pathogenic point mutations in humans. The ability to efficiently convert targeted A•T base pairs to G•C could therefore advance the study and treatment of genetic diseases. The deamination of adenine yields inosine, w...
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Full title
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5726555
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5726555
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature24644
