Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and im...
Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice
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Author / Creator
Wali, Jibran A , Galic, Sandra , Tan, Christina YR , Gurzov, Esteban N , Frazier, Ann E , Connor, Timothy , Ge, Jingjing , Pappas, Evan G , Stroud, David , Varanasi, L Chitra , Selck, Claudia , Ryan, Michael T , Thorburn, David R , Kemp, Bruce E , Krishnamurthy, Balasubramanian , Kay, Thomas WH , McGee, Sean L and Thomas, Helen E
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary conservation and the many other reported binding partners suggest an additional function not directly linked to apoptosis regulation. To identify such a function, we studied mice lacking the BH3-only protein BIM. BIM
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Full title
Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5729528
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5729528
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2017.168
