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mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5740254

mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

About this item

Full title

mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

Publisher

United States: John Wiley & Sons, Inc

Journal title

Annals of clinical and translational neurology, 2017-12, Vol.4 (12), p.844-858

Language

English

Formats

Publication information

Publisher

United States: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

Objectives
There is a critical need to develop effective treatments for diabetic neuropathy. This study determined if a selective mGluR2/3 receptor agonist prevented or treated experimental diabetic peripheral neuropathy (DPN) through glutamate recycling and improved mitochondrial function.
Methods
Adult male streptozotocin treated Sprague...

Alternative Titles

Full title

mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5740254

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5740254

Other Identifiers

ISSN

2328-9503

E-ISSN

2328-9503

DOI

10.1002/acn3.484

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