Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
About this item
Full title
Author / Creator
Apicco, Daniel J. , Ash, Peter E. A. , Maziuk, Brandon , LeBlang, Chelsey , Medalla, Maria , Al Abdullatif, Ali , Ferragud, Antonio , Botelho, Emily , Ballance, Heather I. , Dhawan, Uma , Boudeau, Samantha , Cruz, Anna Lourdes , Kashy, Daniel , Wong, Aria , Goldberg, Lisa R. , Yazdani, Neema , Zhang, Cheng , Ung, Choong Y. , Tripodis, Yorghos , Kanaan, Nicholas M. , Ikezu, Tsuneya , Cottone, Pietro , Leszyk, John , Li, Hu , Luebke, Jennifer , Bryant, Camron D. and Wolozin, Benjamin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo protects against neurodegeneration and prolongs survival in transgenic P301S Tau mice. Biochemical fractionation shows co-enrichment and co-localization of tau oligomers an...
Alternative Titles
Full title
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
Authors, Artists and Contributors
Author / Creator
Ash, Peter E. A.
Maziuk, Brandon
LeBlang, Chelsey
Medalla, Maria
Al Abdullatif, Ali
Ferragud, Antonio
Botelho, Emily
Ballance, Heather I.
Dhawan, Uma
Boudeau, Samantha
Cruz, Anna Lourdes
Kashy, Daniel
Wong, Aria
Goldberg, Lisa R.
Yazdani, Neema
Zhang, Cheng
Ung, Choong Y.
Tripodis, Yorghos
Kanaan, Nicholas M.
Ikezu, Tsuneya
Cottone, Pietro
Leszyk, John
Li, Hu
Luebke, Jennifer
Bryant, Camron D.
Wolozin, Benjamin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5745051
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5745051
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-017-0022-z
