Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive defic...
Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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In rodent models of Alzheimer's disease (AD) and epilepsy, seizure-dependent induction of ΔFosB results in epigenetic silencing of calbindin. Hippocampal inhibition of ΔFosB or elevation of calbindin rescues spatial memory deficits in mouse models of AD.
The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognitio...
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Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5747956
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5747956
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4413
