RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The enzyme RIPK1 functions through its RHIM domain to prevent ZBP1-mediated activation of RIPK3–MLKL-dependent necroptosis, thus preventing perinatal lethality and skin inflammation in adult mice.
RIPK1 inhibition of inflammation
Manolis Pasparakis and colleagues report that receptor-interacting protein kinase 1 (RIPK1) functions via its RIP...
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Full title
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5755685
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5755685
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature20558
