Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
About this item
Full title
Author / Creator
Meakin, Paul J. , Jalicy, Susan M. , Montagut, Gemma , Allsop, David J. P. , Cavellini, Daniella L. , Irvine, Stuart W. , McGinley, Christopher , Liddell, Mary K. , McNeilly, Alison D. , Parmionova, Karolina , Liu, Yu-Ru , Bailey, Charlotte L. S. , Dale, J. Kim , Heisler, Lora K. , McCrimmon, Rory J. and Ashford, Michael L. J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Obesity places an enormous medical and economic burden on society. The principal driver appears to be central leptin resistance with hyperleptinemia. Accordingly, a compound that reverses or prevents leptin resistance should promote weight normalisation and improve glucose homeostasis. The protease Bace1 drives beta amyloid (Aβ) production with obe...
Alternative Titles
Full title
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758523
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758523
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-18388-6
