Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily. It functions as a ligand-activated transcription factor and plays important roles in the regulation of adipocyte differentiation, insulin resistance, and inflammation. Here, we report the crystal structures of PPARγ in complex with lobeglitazone, a...
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Full title
Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758645
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758645
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-18274-1
