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WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cell...

WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cell...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758668

WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells

About this item

Full title

WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells

Publisher

London: Nature Publishing Group UK

Journal title

Acta pharmacologica Sinica, 2018-01, Vol.39 (1), p.35-47

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Hypotonic challenge evoked vascular cell proliferation through activation of volume-regulated Cl^- channel (VRCC), leading to a decrease in the intracellular Cl^- concentration ([Cl^-]i). We hypothesize that the decrease in [Cl^-]i may activate one or several Cl^--sensitive kinases, resulting in a subsequent signaling cascade. In this study we demo...

Alternative Titles

Full title

WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758668

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758668

Other Identifiers

ISSN

1671-4083

E-ISSN

1745-7254

DOI

10.1038/aps.2017.56

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