A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
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Author / Creator
The International Genomics of Alzheimer's Project , The Alzheimer's Disease Neuroimaging Initiative , Alzheimer's Disease Neuroimaging Initiative , International Genomics of Alzheimer's Project , Huang, Kuan-lin , Marcora, Edoardo , Pimenova, Anna A , Di Narzo, Antonio F , Kapoor, Manav , Jin, Sheng Chih , Harari, Oscar , Bertelsen, Sarah , Fairfax, Benjamin P , Czajkowski, Jake , Chouraki, Vincent , Grenier-Boley, Benjamin , Bellenguez, Céline , Deming, Yuetiva , McKenzie, Andrew , Raj, Towfique , Renton, Alan E , Budde, John , Smith, Albert , Fitzpatrick, Annette , Bis, Joshua C , DeStefano, Anita , Adams, Hieab H H , Ikram, M Arfan , van der Lee, Sven , Del-Aguila, Jorge L , Fernandez, Maria Victoria , Ibañez, Laura , Sims, Rebecca , Escott-Price, Valentina , Mayeux, Richard , Haines, Jonathan L , Farrer, Lindsay A , Pericak-Vance, Margaret A , Lambert, Jean Charles , van Duijn, Cornelia , Launer, Lenore , Seshadri, Sudha , Williams, Julie , Amouyel, Philippe , Schellenberg, Gerard D , Zhang, Bin , Borecki, Ingrid , Kauwe, John S K , Cruchaga, Carlos , Hao, Ke and Goate, Alison M
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The authors identified a protective genetic allele associated with lower PU.1 (
SPI1
) expression in myeloid cells by conducting a genome-wide scan of Alzheimer's disease (AD). PU.1 binds the promoters of AD-associated genes (e.g.,
CD33
,
MS4A4A
&
MS4A6A
,
TYROBP
) and modulates their expression, suggesting it may redu...
Alternative Titles
Full title
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
Authors, Artists and Contributors
Author / Creator
The Alzheimer's Disease Neuroimaging Initiative
Alzheimer's Disease Neuroimaging Initiative
International Genomics of Alzheimer's Project
Huang, Kuan-lin
Marcora, Edoardo
Pimenova, Anna A
Di Narzo, Antonio F
Kapoor, Manav
Jin, Sheng Chih
Harari, Oscar
Bertelsen, Sarah
Fairfax, Benjamin P
Czajkowski, Jake
Chouraki, Vincent
Grenier-Boley, Benjamin
Bellenguez, Céline
Deming, Yuetiva
McKenzie, Andrew
Raj, Towfique
Renton, Alan E
Budde, John
Smith, Albert
Fitzpatrick, Annette
Bis, Joshua C
DeStefano, Anita
Adams, Hieab H H
Ikram, M Arfan
van der Lee, Sven
Del-Aguila, Jorge L
Fernandez, Maria Victoria
Ibañez, Laura
Sims, Rebecca
Escott-Price, Valentina
Mayeux, Richard
Haines, Jonathan L
Farrer, Lindsay A
Pericak-Vance, Margaret A
Lambert, Jean Charles
van Duijn, Cornelia
Launer, Lenore
Seshadri, Sudha
Williams, Julie
Amouyel, Philippe
Schellenberg, Gerard D
Zhang, Bin
Borecki, Ingrid
Kauwe, John S K
Cruchaga, Carlos
Hao, Ke
Goate, Alison M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5759334
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5759334
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4587
