Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque t...
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
About this item
Full title
Author / Creator
He, Zhuohao , Guo, Jing L , McBride, Jennifer D , Narasimhan, Sneha , Kim, Hyesung , Changolkar, Lakshmi , Zhang, Bin , Gathagan, Ronald J , Yue, Cuiyong , Dengler, Christopher , Stieber, Anna , Nitla, Magdalena , Coulter, Douglas A , Abel, Ted , Brunden, Kurt R , Trojanowski, John Q and Lee, Virginia M-Y
Publisher
New York: Springer New York
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer New York
Subjects
More information
Scope and Contents
Contents
Through injection of human Alzheimer's disease (AD) brain extracts containing pathological tau protein into transgenic mouse lines harboring different levels of amyloid plaque burden, the authors find that the presence of amyloid plaques modifies endogenous pools of tau protein, creating a unique environment required for the seeding and spreading o...
Alternative Titles
Full title
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5760353
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5760353
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4443
