Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing ef...
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
About this item
Full title
Author / Creator
Canny, Marella D , Moatti, Nathalie , Wan, Leo C K , Fradet-Turcotte, Amélie , Krasner, Danielle , Mateos-Gomez, Pedro A , Zimmermann, Michal , Orthwein, Alexandre , Juang, Yu-Chi , Zhang, Wei , Noordermeer, Sylvie M , Seclen, Eduardo , Wilson, Marcus D , Vorobyov, Andrew , Munro, Meagan , Ernst, Andreas , Ng, Timothy F , Cho, Tiffany , Cannon, Paula M , Sidhu, Sachdev S , Sicheri, Frank and Durocher, Daniel
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Modulation of DNA repair pathway choice by a potent inhibitor of 53BP1 improves the efficiency of homology-dependent genome editing in human and mouse cells.
Programmable nucleases, such as Cas9, are used for precise genome editing by homology-dependent repair (HDR)
1
,
2
,
3
. However, HDR efficiency is constrained by competit...
Alternative Titles
Full title
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
Authors, Artists and Contributors
Author / Creator
Moatti, Nathalie
Wan, Leo C K
Fradet-Turcotte, Amélie
Krasner, Danielle
Mateos-Gomez, Pedro A
Zimmermann, Michal
Orthwein, Alexandre
Juang, Yu-Chi
Zhang, Wei
Noordermeer, Sylvie M
Seclen, Eduardo
Wilson, Marcus D
Vorobyov, Andrew
Munro, Meagan
Ernst, Andreas
Ng, Timothy F
Cho, Tiffany
Cannon, Paula M
Sidhu, Sachdev S
Sicheri, Frank
Durocher, Daniel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5762392
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5762392
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.4021
