RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
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Author / Creator
Qutob, Nouar , Masuho, Ikuo , Alon, Michal , Emmanuel, Rafi , Cohen, Isadora , Di Pizio, Antonella , Madore, Jason , Elkahloun, Abdel , Ziv, Tamar , Levy, Ronen , Gartner, Jared J. , Hill, Victoria K. , Lin, Jimmy C. , Hevroni, Yael , Greenberg, Polina , Brodezki, Alexandra , Rosenberg, Steven A. , Kosloff, Mickey , Hayward, Nicholas K. , Admon, Arie , Niv, Masha Y. , Scolyer, Richard A. , Martemyanov, Kirill A. and Samuels, Yardena
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Analysis of 501 melanoma exomes revealed
RGS7
, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene.
RGS7
was mutated in 11% of melanomas and was found to harbor three recurrent mutations (p.R44C, p.E383K and p.R416Q). Structural modeling of the most common recurrent mutation of the three (p.R44C) predicted...
Alternative Titles
Full title
RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
Authors, Artists and Contributors
Author / Creator
Masuho, Ikuo
Alon, Michal
Emmanuel, Rafi
Cohen, Isadora
Di Pizio, Antonella
Madore, Jason
Elkahloun, Abdel
Ziv, Tamar
Levy, Ronen
Gartner, Jared J.
Hill, Victoria K.
Lin, Jimmy C.
Hevroni, Yael
Greenberg, Polina
Brodezki, Alexandra
Rosenberg, Steven A.
Kosloff, Mickey
Hayward, Nicholas K.
Admon, Arie
Niv, Masha Y.
Scolyer, Richard A.
Martemyanov, Kirill A.
Samuels, Yardena
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5766496
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5766496
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-18851-4
