SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis
SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis
About this item
Full title
Author / Creator
Martinelli, G , Mancini, M , De Benedittis, C , Rondoni, M , Papayannidis, C , Manfrini, M , Meggendorfer, M , Calogero, R , Guadagnuolo, V , Fontana, M C , Bavaro, L , Padella, A , Zago, E , Pagano, L , Zanotti, R , Scaffidi, L , Specchia, G , Albano, F , Merante, S , Elena, C , Savini, P , Gangemi, D , Tosi, P , Ciceri, F , Poletti, G , Riccioni, L , Morigi, F , Delledonne, M , Haferlach, T , Cavo, M , Valent, P and Soverini, S
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The molecular basis of advanced systemic mastocytosis (SM) is not fully understood and despite novel therapies the prognosis remains dismal. Exome sequencing of an index-patient with mast cell leukemia (MCL) uncovered biallelic loss-of-function mutations in the
SETD2
histone methyltransferase gene. Copy-neutral loss-of-heterozygosity at 3p21....
Alternative Titles
Full title
SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis
Authors, Artists and Contributors
Author / Creator
Mancini, M
De Benedittis, C
Rondoni, M
Papayannidis, C
Manfrini, M
Meggendorfer, M
Calogero, R
Guadagnuolo, V
Fontana, M C
Bavaro, L
Padella, A
Zago, E
Pagano, L
Zanotti, R
Scaffidi, L
Specchia, G
Albano, F
Merante, S
Elena, C
Savini, P
Gangemi, D
Tosi, P
Ciceri, F
Poletti, G
Riccioni, L
Morigi, F
Delledonne, M
Haferlach, T
Cavo, M
Valent, P
Soverini, S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5770597
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5770597
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2017.183
