The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s di...
The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease
About this item
Full title
Author / Creator
Chen, Chun , Wang, Zhihao , Zhang, Zhentao , Liu, Xia , Kang, Seong Su , Zhang, Ying and Ye, Keqiang
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer’s disease (AD). However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic (PK) profile. To alleviate these preclinical obstacles, we used a prodrug strategy for elevati...
Alternative Titles
Full title
The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5777001
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5777001
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1718683115
