Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mou...
Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The hereditary neurodegenerative disorder spinal muscular atrophy (SMA) is characterized by the loss of spinal cord motor neurons and skeletal muscle atrophy. SMA is caused by mutations of the survival motor neuron (SMN) gene leading to a decrease in SMN protein levels. The SMN deficiency alters nuclear body formation and whether it can contribute...
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Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5794986
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5794986
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-20219-1
