Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselecti...
Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Bioconversion is useful to produce optically pure enantiomers in the pharmaceutical industry, thereby avoiding problems with side reactions during organic synthesis processes. A short-chain dehydrogenase/reductase from
Serratia marcescens
BCRC 10948 (
Sm
SDR) can stereoselectively convert 1-(3-hydroxyphenyl)-2-(methylamino) ethanone (HP...
Alternative Titles
Full title
Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5797133
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5797133
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-19235-y
