Loss-of-function uORF mutations in human malignancies
Loss-of-function uORF mutations in human malignancies
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Author / Creator
Schulz, Julia , Mah, Nancy , Neuenschwander, Martin , Kischka, Tabea , Ratei, Richard , Schlag, Peter M. , Castaños-Vélez, Esmeralda , Fichtner, Iduna , Tunn, Per-Ulf , Denkert, Carsten , Klaas, Oliver , Berdel, Wolfgang E. , von Kries, Jens P. , Makalowski, Wojciech , Andrade-Navarro, Miguel A. , Leutz, Achim and Wethmar, Klaus
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Ribosome profiling revealed widespread translational activity at upstream open reading frames (uORFs) and validated uORF-mediated translational control as a commonly repressive mechanism of gene expression. Translational activation of proto-oncogenes through loss-of-uORF mutations has been demonstrated, yet a systematic search for cancer-associated...
Alternative Titles
Full title
Loss-of-function uORF mutations in human malignancies
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5799362
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5799362
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-19201-8
