Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens
About this item
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Combinatorial CRISPR screens are improved by using Cas9 enzymes from two different organisms.
Combinatorial genetic screening using CRISPR–Cas9 is a useful approach to uncover redundant genes and to explore complex gene networks. However, current methods suffer from interference between the single-guide RNAs (sgRNAs) and from limited gene target...
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Full title
Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5800952
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5800952
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.4048
