TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
About this item
Full title
Author / Creator
Chou, Ching-Chieh , Zhang, Yi , Umoh, Mfon E. , Vaughan, Spencer W. , Lorenzini, Ileana , Liu, Feilin , Sayegh, Melissa , Donlin-Asp, Paul G. , Chen, Yu Han , Duong, Duc M. , Seyfried, Nicholas T. , Powers, Maureen A. , Kukar, Thomas , Hales, Chadwick M. , Gearing, Marla , Cairns, Nigel J. , Boylan, Kevin B. , Dickson, Dennis W. , Rademakers, Rosa , Zhang, Yong-Jie , Petrucelli, Leonard , Sattler, Rita , Zarnescu, Daniela C. , Glass, Jonathan D. and Rossoll, Wilfried
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia disease spectrum (ALS/FTD). However, the composition of aggregates and their contribution to the disease process remain unknown. Here we used proximity-depende...
Alternative Titles
Full title
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
Authors, Artists and Contributors
Author / Creator
Zhang, Yi
Umoh, Mfon E.
Vaughan, Spencer W.
Lorenzini, Ileana
Liu, Feilin
Sayegh, Melissa
Donlin-Asp, Paul G.
Chen, Yu Han
Duong, Duc M.
Seyfried, Nicholas T.
Powers, Maureen A.
Kukar, Thomas
Hales, Chadwick M.
Gearing, Marla
Cairns, Nigel J.
Boylan, Kevin B.
Dickson, Dennis W.
Rademakers, Rosa
Zhang, Yong-Jie
Petrucelli, Leonard
Sattler, Rita
Zarnescu, Daniela C.
Glass, Jonathan D.
Rossoll, Wilfried
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5800968
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5800968
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-017-0047-3
