Genome‐wide association study of a nicotine metabolism biomarker in African American smokers: impact...
Genome‐wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences
About this item
Full title
Author / Creator
on behalf of the PGRN‐PNAT Research Group , PGRN-PNAT Research Group , Chenoweth, Meghan J. , Ware, Jennifer J. , Zhu, Andy Z. X. , Cole, Christopher B. , Cox, Lisa Sanderson , Nollen, Nikki , Ahluwalia, Jasjit S. , Benowitz, Neal L. , Schnoll, Robert A. , Hawk, Larry W. , Cinciripini, Paul M. , George, Tony P. , Lerman, Caryn , Knight, Joanne and Tyndale, Rachel F.
Publisher
England: Blackwell Publishing Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: Blackwell Publishing Ltd
Subjects
More information
Scope and Contents
Contents
Background and aims
The activity of CYP2A6, the major nicotine‐inactivating enzyme, is measurable in smokers using the nicotine metabolite ratio (NMR; 3′hydroxycotinine/cotinine). Due to its role in nicotine clearance, the NMR is associated with smoking behaviours and response to pharmacotherapies. The NMR is highly heritable (~80%), and on aver...
Alternative Titles
Full title
Genome‐wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences
Authors, Artists and Contributors
Author / Creator
PGRN-PNAT Research Group
Chenoweth, Meghan J.
Ware, Jennifer J.
Zhu, Andy Z. X.
Cole, Christopher B.
Cox, Lisa Sanderson
Nollen, Nikki
Ahluwalia, Jasjit S.
Benowitz, Neal L.
Schnoll, Robert A.
Hawk, Larry W.
Cinciripini, Paul M.
George, Tony P.
Lerman, Caryn
Knight, Joanne
Tyndale, Rachel F.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5807179
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5807179
Other Identifiers
ISSN
0965-2140
E-ISSN
1360-0443
DOI
10.1111/add.14032
