OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses...
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
About this item
Full title
Author / Creator
Marchetti, Carlo , Swartzwelter, Benjamin , Gamboni, Fabia , Neff, Charles P. , Richter, Katrin , Azam, Tania , Carta, Sonia , Tengesdal, Isak , Nemkov, Travis , D’Alessandro, Angelo , Henry, Curtis , Jones, Gerald S. , Goodrich, Scott A. , St. Laurent, Joseph P. , Jones, Terry M. , Scribner, Curtis L. , Barrow, Robert B. , Altman, Roy D. , Skouras, Damaris B. , Gattorno, Marco , Grau, Veronika , Janciauskiene, Sabina , Rubartelli, Anna , Joosten, Leo A. B. and Dinarello, Charles A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Activation of the NLRP3 inflammasome induces maturation of IL-1β and IL-18, both validated targets for treating acute and chronic inflammatory diseases. Here, we demonstrate that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome. In vitro, nanomolar concentrations of OLT1177 reduced IL-1β and IL-18...
Alternative Titles
Full title
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
Authors, Artists and Contributors
Author / Creator
Swartzwelter, Benjamin
Gamboni, Fabia
Neff, Charles P.
Richter, Katrin
Azam, Tania
Carta, Sonia
Tengesdal, Isak
Nemkov, Travis
D’Alessandro, Angelo
Henry, Curtis
Jones, Gerald S.
Goodrich, Scott A.
St. Laurent, Joseph P.
Jones, Terry M.
Scribner, Curtis L.
Barrow, Robert B.
Altman, Roy D.
Skouras, Damaris B.
Gattorno, Marco
Grau, Veronika
Janciauskiene, Sabina
Rubartelli, Anna
Joosten, Leo A. B.
Dinarello, Charles A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5816172
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5816172
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1716095115
