Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Huntington’s disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and the important role of inhibition in learning and me...
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Full title
Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5816181
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5816181
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1716871115
