Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very L...
Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency
About this item
Full title
Author / Creator
Hopiavuori, Blake R. , Deák, Ferenc , Wilkerson, Joseph L. , Brush, Richard S. , Rocha-Hopiavuori, Nicole A. , Hopiavuori, Austin R. , Ozan, Kathryn G. , Sullivan, Michael T. , Wren, Jonathan D. , Georgescu, Constantin , Szweda, Luke , Awasthi, Vibhudutta , Towner, Rheal , Sherry, David M. , Anderson, Robert E. and Agbaga, Martin-Paul
Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
Subjects
More information
Scope and Contents
Contents
Lipids are essential components of the nervous system. However, the functions of very long-chain fatty acids (VLC-FA; ≥ 28 carbons) in the brain are unknown. The enzyme ELOngation of Very Long-chain fatty acids-4 (ELOVL4) catalyzes the rate-limiting step in the biosynthesis of VLC-FA (Agbaga et al., Proc Natl Acad Sci USA 105(35): 12843–12848,
2...
Alternative Titles
Full title
Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency
Authors, Artists and Contributors
Author / Creator
Deák, Ferenc
Wilkerson, Joseph L.
Brush, Richard S.
Rocha-Hopiavuori, Nicole A.
Hopiavuori, Austin R.
Ozan, Kathryn G.
Sullivan, Michael T.
Wren, Jonathan D.
Georgescu, Constantin
Szweda, Luke
Awasthi, Vibhudutta
Towner, Rheal
Sherry, David M.
Anderson, Robert E.
Agbaga, Martin-Paul
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5820379
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5820379
Other Identifiers
ISSN
0893-7648
E-ISSN
1559-1182
DOI
10.1007/s12035-017-0824-8
