ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The NLRC4 inflammasome recognizes bacterial flagellin and components of the type III secretion apparatus. NLRC4 stimulation leads to caspase-1 activation followed by a rapid lytic cell death known as pyroptosis. NLRC4 is linked to pathogen-free auto-inflammatory diseases, suggesting a role for NLRC4 in sterile inflammation. Here, we show that NLRC4...
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ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5830643
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5830643
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-21998-3
