Aging and neurodegeneration are associated with increased mutations in single human neurons
Aging and neurodegeneration are associated with increased mutations in single human neurons
About this item
Full title
Author / Creator
Lodato, Michael A. , Rodin, Rachel E. , Bohrson, Craig L. , Coulter, Michael E. , Barton, Alison R. , Kwon, Minseok , Sherman, Maxwell A. , Vitzthum, Carl M. , Luquette, Lovelace J. , Yandava, Chandri N. , Yang, Pengwei , Chittenden, Thomas W. , Hatem, Nicole E. , Ryu, Steven C. , Woodworth, Mollie B. , Park, Peter J. and Walsh, Christopher A.
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: The American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Most neurons that make up the human brain are postmitotic, living and functioning for a very long time without renewal (see the Perspective by Lee). Bae
et al.
examined the genomes of single neurons from the prenatal developing human brain. Both the type of mutation and the rates of accumulation changed between gastrulation and neurogenesis....
Alternative Titles
Full title
Aging and neurodegeneration are associated with increased mutations in single human neurons
Authors, Artists and Contributors
Author / Creator
Rodin, Rachel E.
Bohrson, Craig L.
Coulter, Michael E.
Barton, Alison R.
Kwon, Minseok
Sherman, Maxwell A.
Vitzthum, Carl M.
Luquette, Lovelace J.
Yandava, Chandri N.
Yang, Pengwei
Chittenden, Thomas W.
Hatem, Nicole E.
Ryu, Steven C.
Woodworth, Mollie B.
Park, Peter J.
Walsh, Christopher A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5831169
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5831169
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aao4426
