EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblast...
EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Mucopolysaccharidosis (MPS) IIIB is an inherited lysosomal storage disease caused by the deficiency of the enzyme α-
N
-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation. The defective lysosomal clearance of undigested HS results in dysfunction of multiple tissues and organs. We recently demonstrated that the murine...
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EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5833457
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5833457
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-017-0187-0
