Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion from cancer cells. Here, we report the near-atomic resolution cryo-EM structure of nucleotide-free ABCB1 trapped by an engineered disulfide cross-link between the...
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Full title
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5834697
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5834697
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1717044115
