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KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5841452

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

About this item

Full title

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2017-12, Vol.552 (7684), p.273-277

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The histone acetyl transferase KAT2A (also known as GCN5) can also catalyse histone succinylation, with the α-KGDH complex providing a local source of succinyl-CoA.
GCN5 in histone succyinylation
Succinylation of lysines has been identified as a post-translational modification of histones, but the enzymes that deposit it and its functional co...

Alternative Titles

Full title

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5841452

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5841452

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature25003

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